Qantas and its pilots have failed to reach an agreement and are now headed for binding arbitration.

A Qantas spokesman said today the union and the airline decided it "was not possible to reach an agreement".

The matter will now go to binding arbitration, he said.

But the Australian International Pilots Association (AIPA) has accused the airline of sabotaging the negotiations.

In a statement, the union said it would be holding a press conference in Sydney "regarding Qantas's decision to terminate negotiations".

AIPA, as well as the Australian Licensed Aircraft Engineers Association and the Transport Workers Union (TWU) were ordered to go before Fair Work Australia and end all industrial action after Qantas announced on October 29 it had grounded its entire fleet and threatened to lock out staff.

Qantas remains in talks with the engineers and the TWU, who represent ground staff and catering workers.

But TWU boss Tony Sheldon has warned it's unlikely an agreement will be reached and has called for the airline to extend negotiations for another 21 days.

The TWU wants a job security clause included in any agreement with the airline.

The union says the latest offer from the airline on wage increases and job security is less than Qantas offered four weeks ago.